FMU Article - The CoQ10-Statin Secret

By Ronald Grisanti D.C., D.A.B.C.O., D.A.C.B.N., M.S. for The Functional Medicine University. Copied with permission.


The medical literature clearly shows that statin medications like Lipitor, Crestor, Lorstat & Zocor shut down the production of one of the most important nutrients in the body. And I am referring to Co-Enzyme Q10 (CoQ10).

What many people are unaware of is the fact that when CoQ10 is depleted it causes the LDL cholesterol to become oxidized. This in turn sets off a cascade of events making the LDL cholesterol drill holes in the arterial wall causing major inflammation. This inflammation sets you up for an increased risk of getting a heart attack or stroke.

This is a major reason why taking statin drugs is no guarantee you will not die of a heart attack.



I have to admit I am at a total loss why any doctor would prescribe a statin medication without adding the life-saving CoQ10. This may be hard to swallow (excuse the pun) but it should be illegal to prescribe a statin without also prescribing CoQ10.

The following list of health challenges should be a wake up call for people who believe they are safe taking statins without CoQ10. CoQ10 deficiency can cause fatal cardiomyopathy, heart attack, congestive heart failure (which usually carries a death sentence of 5 years), exhaustion, cancer, myopathy, depression resistant to anti-depressants, high blood pressure, gum disease and tooth loss, hair loss, liver disease, sudden complete memory loss or amnesia, cataracts, angina, cancer, folic acid deficiency, damaged cell membranes, and much more.

In fact, it not only increases you from getting a variety of diseases but low CoQ10 levels predict that you can die within 6 months.

So you can see that any doctor who prescribes a statin medication then turns you loose without also prescribing CoQ10 shows lack of scientific knowledge of the very drug he is authorized to prescribe. Take a look at the wealth of scientific references listed below.

Now if you think I am being a bold about what I have just shared with you please understand that this is serious.

Here is something that will shock many of you.

Back in 1990s, the pharmaceutical giant, Merck, decided to add CoQ10 to a statin medication. They even went so far as to get a patent. The patent number is 4,933,165.

Go ahead and download the patent document:

//www.functionalmedicineuniversity.com/statin-CoQ10.pdf


So you may ask why in the world would they produce a statin with CoQ10 and the answer is quite obvious. They knew the seriousness of selling the world on statins without CoQ10.

Now you may be thinking whatever happened to this drug. Well it never came to the marketplace. Not sure why but again they wouldn't have created this combination statin-CoQ10 drug if they were not warned of the serious consequences of promoting a statin without CoQ10.

Hmmm.. makes me very suspicious...


If you are on a statin medication, I urge you to insist that your doctor checks your CoQ10 levels. You can easily have this done by getting an CardioION test which includes a direct test for CoQ10 and a more sensitive test called hydroxymethylglutarate.  This is an organic acid assay which will show you if a particular dose is high enough for your body.


Note: In New Zealand we don't have access to the CardioION test. However a comprehensive Organic Acids Test (OAT ) - Organix Comprehensive Profile by Genova diagnostics includes the test for Hydroxymethylglutarate. It is a urine test that costs around $420 NZ. You can also check you levels of oxidised LDL in your blood after fasting for around $105 NZ (Dunwoody Labs). These tests are not funded by our medical system and require referral from a holistic naturopath or functional medicine practitioner.

References:

  • Thomas S. R., Neuzil J., Stocker R, Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism of coenzyme Q in atherogenesis? Mol Asp Med, 18 (suppl.): s 85-103, 1997

  • Bargossi AM, Battino M, Gaddi A, et at. Exogenous CoQ10 preserves plasma ubiquinol levels in patients treated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, Internal J Clin Lab Res, 24: 171-6, 1994

  • Fuke C, Krikorian, SA, Couris RR, Coenzyme CoQ10: A review of essential functions and clinical trials, Pharmacist, 28-41, Oct 2000

  • Langsjoen PH, Langsjoen AM, Coenzyme Q10 in cardiovascular disease with emphasis on heart failure and myocardial ischaemia, Asia Pacific Heart J ,7; 3: 160-168, 1998

  • Langsjoen PH, et al, Treatment of statin adverse effects with supplemental coenzyme Q10 and statin drug discontinuation, BioFactors, 25 (1-4): 147-52, 2005

  • Langsjoen PH, et al, The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications, BioFactors, 18 (1-4): 101-11, 2003

  • Mabuchi H, et al, Reduction of serum ubiquinol-10 and a ubiquinone-10 levels by atorvastatin in hypercholesterolemia, patients, J Atheroscler Thromb, 12; 2:111-19, 2005

  • Lamperti C, Muscle, coenzyme Q10 level in statin-related myopathy, Arch Neurol, 62; 11: 1109-12, Nov 2005

  • Mortensen AS, et al, Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure, Int J Tissue React, 12; 3: 155-62, 1990

  • Folkers K, Langsjoen P, Tamagawa H, Lovastatin decreases coenzyme levels in humans, Proc Nall Acad Sci USA, 1990; 87:8931-34

  • Bliznakov EG, Wilkins DJ, Biochemical and clinical consequences of inhibiting coenzyme Q10 biosynthesis by lipid-lowering HMG COA reductase inhibitors (statins): a critical overview, Advances in Therapy, 15; 4:219-28, Jul/Aug 1998

  • Ghirlanda G, Oradei A, Manto A, et al, Evidence of plasma CoQ 10-lowering effect of HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study, J Clin Pharmacol, 33: 226-29, 1993

  • Willis RA. Folkers K, Tucker JL, Tamagawa H., et al., Lovastatin decreases coenzyme Q levels in rats, Proc Nat Acad Sci USA, 87: 8928-30. 1990

  • Folkers K, Langsjoen P, et al, Lovastatin decreases coenzyme Q10 levels in humans, Proc Nat Acad Sci USA, 87:8931-4, 1990

  • Bliznakov EG, Lipid-lowering to drugs (statins), cholesterol, and coenzyme Q10. The Baycol case-¬-a modern Pandora's box, Biomed Pharmacother, 56:56-9, 2002

  • Jameson S, Statistical data support prediction of death within six months on low levels of coenzyme Ql0 and other entities, Clin Invest, 71 (suppl):137-39, 1993


#hearthealth #statins #cholesterol #coQ10

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